Shargel and Yu's Applied Biopharmaceutics and Pharmacokinetics 8th edition (eighth edition)

About this book

Shargel and Yu's Applied Biopharmaceutics and Pharmacokinetics 8th edition by Murray P. Ducharme and Leon Shargel explains the principles that determine drug absorption, distribution, metabolism, elimination, and therapeutic response. The book connects biopharmaceutics and pharmacokinetics with patient drug therapy and rational pharmaceutical product development.

The 8th edition covers drug absorption, physiological factors affecting absorption, bioavailability, bioequivalence, pharmacokinetic models, intravenous infusion, multiple dosing, nonlinear pharmacokinetics, protein binding, clearance, and pharmacodynamics. It also examines novel and complex dosage forms, therapeutic equivalence, generic drugs, biosimilars, and the use of pharmacokinetic and pharmacodynamic principles during clinical drug development.

This textbook is intended primarily for pharmacy and pharmaceutical science students studying biopharmaceutics, pharmacokinetics, and clinical pharmacology. Practice problems, clinical examples, calculation based applications, and questions help students connect mathematical pharmacokinetic principles with dosage regimen design, drug product performance, therapeutic monitoring, and interpretation of concentration time data.

PharmD students, pharmacy students, pharmaceutical science students, clinical pharmacology trainees, pharmacists, and professionals involved in drug development can use this edition to perform pharmacokinetic calculations, evaluate bioavailability and bioequivalence, and understand factors influencing drug response. The 2022 8th edition is available as a searchable PDF enhanced digital version with instant access for coursework, calculations, clinical study, and pharmaceutical research.