Guyton and Hall Textbook of Medical Physiology 15th edition (fifteenth edition)

About this book

Guyton and Hall Textbook of Medical Physiology 15th edition by John E. Hall and Michael E. Hall explains the fundamental physiological mechanisms that maintain normal human function. The book connects cellular processes with organ system physiology and integrated body regulation, helping students understand how the nervous, cardiovascular, respiratory, renal, endocrine, gastrointestinal, and reproductive systems interact to maintain homeostasis.

The 15th edition covers membrane transport, nerve and muscle physiology, autonomic regulation, sensory and motor systems, cardiovascular dynamics, blood pressure control, respiratory mechanics and gas exchange, kidney function, body fluid regulation, acid base balance, endocrine hormones, reproduction, digestion, metabolism, temperature regulation, and exercise physiology. Updated material also addresses the gut microbiome and clinically important sex differences in physiological values.

This textbook is intended primarily for clinical and preclinical medical students and other health professions students who need a strong foundation in human physiology. Its emphasis on mechanisms, integrated regulation, and clinical connections makes it especially useful for learning how normal physiological processes operate before progressing to pathophysiology, pharmacology, and clinical medicine.

MD students, DO students, physiology students, biomedical science students, and other health professions trainees can use this edition to review core mechanisms, connect organ systems, and prepare for physiology examinations and clinical coursework. The 2025 15th edition is available as a searchable PDF enhanced digital version with instant access for medical physiology coursework, examination preparation, and focused review.